REGENERATIVE / ORTHOBIOLOGICS


Regenerative / Orthobiologic Therapy Options

While all the following treatments show efficacy as single therapies for pain, injured, aged and/or worn down tissue, treatments that combine these modalities are especially promising for all ORTHOPEDIC, ANTI-AGING and SEXUAL WELLNESS indications.


Bone Marrow Aspiration (BMA)

Bone marrow is the spongy tissue found in the center of bones. Its main job is to make the blood cells that circulate in your body, which include immune cells that recognize foreign invaders and fight infection. Bone marrow is unique in that it contains a rich supply of mesenchymal and hematopoeitic stem cells that have been shown to support the repair and growth of bone, cartilage, muscle, marrow, tendons, ligaments and connective tissue.

Under ultrasound guidance, bone marrow is drawn (aspirated) most commonly from the pelvis, but it may be drawn from other sites as well by a simple in-office procedure. Since the patient is given a local anesthetic, very minimal discomfort results from the procedure. The physician then delivers the concentrated bone marrow directly into the application site on your body. This greatly enhances the regenerative healing cascade. The aspirated bone marrow regenerates naturally within the site it was taken from.

Adipose (Fat)

Adipose or fat tissue is an incredibly rich source of mesenchymal stem cells, extracellular matrix, and growth factors. This therapy produces a purified adipose tissue graft, which is readily available for a variety of orthopedic and regenerative applications. This technique has been shown to be very effective in the aesthetic areas of regenerative medicine. This graft is known as a “lipoaspirate.”

To create the lipoaspirate, a small sample of adipose tissue is obtained from the abdomen (love handles) through a quick liposuction procedure. The lipoaspirate is then injected back into your body at the point of injury or desired cosmetic enhancement.

Platelet Rich Plasma (PRP)

A small sample of your blood is drawn (similar to a lab test sample) and placed in a centrifuge that spins the blood at high speeds, separating the platelets from the other components. The concentrated platelet rich plasma (PRP) is then injected into and around the point of injury or cosmetic/functional enhancement, jump-starting and significantly strengthening the body’s natural healing process. 

At Regeneration Pittsburgh, we always start our PRP treatment with a musculoskeletal ultrasound evaluation. Ultrasound helps us pinpoint the exact location of the pain site, making the treatment much more effective for pain relief and healing. Because ultrasound is performed in real-time, our physicians have the ability to watch on a monitor as the needle is placed precisely in the correct position for the injection. 

Amniotic and Umbilical Cord Allograft Injection

The anti-inflammatory properties found in the amniotic and umbilical cord grafts can help reduce swelling and inflammation, as well as speed up the body’s healing process. Many times, simply by reducing the inflammation, pain is alleviated. In addition, amniotic and umbilical cord tissue has an anti-adhesive and antimicrobial property to enhance healing and promote reduced scarring, in addition to germ-fighting capabilities beneficial for wound healing.

Nanoparticles

Mesenchymal growth factors found in bone marrow, adipose tissue, umbilical cord allografts have been at the forefront of regenerative medicine for many years although it will likely be a general consensus that the actual healing will be done by the growth factor secretions or nanoparticles (sometimes referred to as exosomes).  

Nanoparticles have been shown to have many therapeutic applications such as reducing inflammation and facilitating injured tissue healing.


Prolotherapy

Prolotherapy injections use a natural irritant agent. Examples include: Sugar (dextrose or glucose) alone or in combination with glycerin and phenol or Sodium morrhuate (a purified derivative of cod liver oil) is used to initiate the inflammatory and subsequent healing cascade.

Ozone

Ozone Injections, like prolotherapy use a proliferant substance (Ozone or O3, the reactive form of oxygen) to initiate the inflammatory and subsequent healing cascade.

Prolozone

Prolozone Injections use combination of the prolotherapy agent and ozone gas to promote the healing cascade.

During these respective procedures, the proliferant agent is typically used with or preceded by a local anesthetic (lidocaine, procaine, or marcaine). They usually involve a series of injections, ranging from 3 to 10, depending on the condition and the individual being treated.

All of our procedures are intended for homologous use with minimal manipulation and are performed on the same day. We strive to be compliant with the latest relevant FDA regulatory guidelines including IND/BLA, RMAT, section 351 and 361 HCT/P guidelines. Any off label uses of medications or products are fully disclosed. 



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