Alpha 2 Macroglobin (A2M)
what is
Alpha 2 Macroglobin (A2M)
A2M is a naturally occurring protein in your bloodstream that works to trap and remove the enzymes responsible for cartilage breakdown and inflammation. These enzymes—called proteases—accelerate joint damage in conditions like osteoarthritis. A2M acts like a biological “sponge,” binding to these harmful proteins and helping your body clear them out before they can do more harm.
During your treatment, a small sample of your blood is drawn and spun in a centrifuge to isolate the A2M. The concentrated solution is then injected into the joint or injury site using ultrasound guidance for precise placement—stimulating healing and protecting your joint tissue.
HOW IT WORKS
Blood Draw & Separation
Your provider draws a small sample of blood and places it into a centrifuge. This process isolates the A2M protein from other components in your plasma.
A2M Extraction
The isolated A2M is carefully collected and prepared for targeted use. This plasma protein works by binding to the enzymes that contribute to joint degeneration and inflammation.
Targeted Injection
The A2M solution is injected into the affected joint or injury site using ultrasound guidance. Once injected, A2M inactivates harmful proteins, supporting healing and protecting cartilage from further damage.
WHAT THIS TREATMENT TARGETS
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Joint pain from osteoarthritis
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Cartilage degeneration
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Inflammatory joint conditions
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Post-surgical recovery support
Ready to Target Joint Breakdown at the Source?
If you’re looking for a non-surgical, regenerative approach to protect your joints and reduce inflammation, A2M therapy may be the solution.
COMMON QUESTIONS ABOUT A2M THERAPY
A2M is a natural protein found in your blood that neutralizes the enzymes responsible for breaking down cartilage. When injected into a damaged joint, it helps stop the degenerative process and promotes healing.
While PRP and stem cells stimulate healing, A2M specifically targets and neutralizes the destructive proteins that cause cartilage breakdown. It’s often used in conjunction with other regenerative therapies for enhanced outcomes.
A2M is most commonly used for osteoarthritis, joint pain, and early cartilage damage. It can be especially helpful for patients looking to avoid or delay surgery.
Yes. Because A2M is derived from your own blood, the risk of adverse reactions is extremely low. The procedure is performed in-office using ultrasound guidance to ensure precision and comfort.